Formulation development and characterization of in-situ gel of Rizatriptan Benzoate for intranasal delivery
نویسندگان
چکیده
The present investigation was aimed to formulate and characterize ion-activated in-situ gel loaded with Rizatriptan Benzoate (RIZ) for intranasal administration brain targeting. further optimized process formulation parameters by using 32 factorial design. batch having the concentrations of gellan gum HPMC E15 LV 33.83 mg 9.6 respectively. Gel strength mucoadhesive were found be 32.54 sec 2580.50 dynes/cm2 Moreover, improved in-vitro ex-vivo release profile observed in comparison drug solution. In a nutshell, developed holds great promise overcoming limitation associated currently marketed RIZ formulations illustrates potential use administer nasal route targeting.
 Keywords: In-situ gel, benzoate, Ion-activated, Gellan gum, LV, Brain delivery, Migraine
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2021
ISSN: ['2250-1177']
DOI: https://doi.org/10.22270/jddt.v11i1-s.4685